Endocrine Abstracts

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as developmental failure of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism. In contrast, subjects presenting TH were only sporadically involved. In addition, whether the same factors are responsible for development of TH and other forms of thyroid dysgenesis is still to be elucidated. Recent stud...

Thyroid hemiagenesis (TH) is a rare inborn anomaly presenting as failure of the development of one thyroid lobe. Recent research on the molecular background underlying thyroid dysgenesis have mainly focused on patients with congenital hypothyroidism; in contrast, subjects presenting TH were only sporadically involved. Changes in transcription factor genes, including TTF1, TTF2 and PAX8, which play an important role in thyroid embryogenesis, have been postu...